Phosphorus oxychloride PF, pharmaceutical grade 300 kg barrel

“The sale of the product can be completed after your positive verification according to the internal procedure in force in our company. Therefore, this sales proposal is not a binding proposal to conclude a contract until the verification referred to below is positively considered.”

In accordance with Council Regulation (EC) No. 428/2009 of May 5, 2009, as amended amendments establishing the Community export, transfer, brokerage and transit control system for dual-use items, the product is an item of strategic importance and is subject to trade control, including obtaining an export permit and keeping records of trade.

Phosphorus oxychloride is a colorless liquid with a sharp, very characteristic odor. It undergoes hydrolysis very easily, which is accompanied by the emission of fumes, and its products are phosphoric acid and hydrogen chloride. The reaction of oxychloride with water is very rapid. Due to the high exothermicity of the process and the release of large amounts of suffocating hydrogen chloride as a result, transport and storage should be carried out in tightly closed packaging, protected against moisture or flooding. The strong corrosive properties of phosphorus oxychloride affect the type of packaging in which it should be stored and transported. These packagings should be made of a suitable material, preferably steel or Teflon of specified quality.

It is very important to use personal protective equipment when working with phosphorus oxychloride, because it can cause burns in contact with the skin. The product should be protected against both too high temperatures (due to the high vapor pressure of the substance) and too low temperatures (as it begins to solidify at a temperature below 1°C).

Phosphorus oxychloride is produced by the oxidation of phosphorus trichloride, and the production technology used allows for obtaining a product of high purity, i.e. containing very small amounts of phosphorus trichloride. This is the advantage and market advantage of this product, especially when it is used for the synthesis of substances that must be of high purity. The low content of elemental sulfur and heavy metals such as arsenic, iron, lead, nickel, chromium and others is also significant in this case.

POCl ₃ is a high-purity intermediate/raw material, which, thanks to its high reactivity, is an excellent substrate for the synthesis of phosphorus and chlorine compounds, widely used in the chemical and pharmaceutical industries. Its reactivity allows the use of POCl ₃ for the synthesis of, among others, active substances (API, Active Pharmaceutical Ingredient).

Phosphorus oxychloride is most often used as:

• a reagent that introduces phosphorus into the substrate molecule by forming phosphates (phosphorylation);
• chlorinating reagent, used in substitution reactions of hydroxyl groups with a chlorine atom;
• activator in coupling reactions, converting carboxylic or sulfonic/sulfinic acids into their chlorides (more reactive derivatives), coupled with various nucleophiles (e.g. alcohols to form esters or amines to form amides);
• substrate for the synthesis of catalysts, where it serves as a building block for ligands;
• reagent in cyclization processes, e.g. in the synthesis of isoquinolines by the Bischler-Napieralski method.

• CAS number: 10025-87-3
• external appearance at 20-25 ^o C: colorless liquid
• density at 20 ^o C, g/cm ³ : 1.672-1.678
• phosphorus oxychloride, % (m/m): min. 99.5
• alternative names: phosphorus(V) oxychloride; phosphoryl chloride;
• very high purity;
• very low content of impurities, especially heavy metals and elemental sulfur;
• high reactivity that allows it to be used as a raw material for the production of many chemical substances;
• raw material for the pharmaceutical industry;
• raw material for the synthesis of active substances (API, Active Pharmaceutical Ingredient);